J. Segura-Aguilar: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases

Costa, Silvia Lima, Silva, Victor Diogenes Amaral, dos Santos Souza, Cleide, Santos, Cleonice Creusa, Paris, Irmgard, Muñoz, Patricia, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

2

Cell Lines as In Vitro Models for Drug Screening and Toxicity Studies

Allen, David D., Caviedes, Raúl, Cárdenas, Ana María, Shimahara, Takeshi, Segura-Aguilar, Juan, Caviedes, Pablo A.

Journal:

Drug Development and Industrial Pharmacy

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

3

Reduction of Brain Antioxidant Defense Upon Treatment with Butylated Hydroxyanisole (BHA) and Sudan III in Syrian Golden Hamster

Francisco J. Romero, Joaquín Romá, Francisco Bosch-Morell, Belén Romero, Juan Segura-Aguilar, Antonio Llombart-Bosch, Lars Ernster

Journal:

Neurochemical Research

Year:

2000

Language:

english

File:

PDF, 21 KB

english, 2000

4

Nitrobenzimidazoles as Substrates for DT-Diaphorase and Redox Cycling Compounds: Their Enzymatic Reactions and Cytotoxicity

Jonas šarlauskas, Egl≐ Dičkancait≐, Aušra Nemeikait≐, Žilvinas Anusevičius, Henrikas Nivinskas, Juan Segura-Aguilar, Narimantas č≐nas

Journal:

Archives of Biochemistry and Biophysics

Year:

1997

Language:

english

File:

PDF, 206 KB

english, 1997

5

Dopamine Oxidation and Autophagy

Muñoz, Patricia, Huenchuguala, Sandro, Paris, Irmgard, Segura-Aguilar, Juan

Journal:

Parkinson's Disease

Year:

2012

Language:

english

File:

PDF, 3.15 MB

english, 2012

6

Botulinum neurotoxin: Evolution from poison, to research tool - onto medicinal therapeutic and future pharmaceutical panacea

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2007

Language:

english

File:

PDF, 1.50 MB

english, 2007

7

A new direct method for determining superoxide dismutase activity by measuring hydrogen peroxide formation

Juan Segura-Aguilar

Journal:

Chemico-Biological Interactions

Year:

1993

Language:

english

File:

PDF, 488 KB

english, 1993

8

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

Munoz, P., Cardenas, S., Huenchuguala, S., Briceno, A., Couve, E., Paris, I., Segura-Aguilar, J.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 725 KB

english, 2015

9

Comment on: “Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease”

Segura-Aguilar, Juan

Journal:

Year:

2018

Language:

english

File:

PDF, 370 KB

english, 2018

10

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

BAEZ, Sofia, SEGURA-AGUILAR, Juan, WIDERSTEN, Mikael, JOHANSSON, Ann-Sofie, MANNERVIK, Bengt

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 225 KB

english, 1997

11

Neurotoxins as Preclinical Models for Parkinson’s Disease

Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2018

Language:

english

File:

PDF, 524 KB

english, 2018

12

DT-diaphorase-catalyzed two electron reduction of quinone epoxides

Brunmark, Anders, Cadenas, Enrique, Lind, Christina, Segura-Aguilar, Juan, Ernster, Lars

Journal:

Free Radical Biology and Medicine

Year:

1987

Language:

english

File:

PDF, 568 KB

english, 1987

13

Neurotoxins and neurotoxicity mechanisms. an overview

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Year:

2006

Language:

english

File:

PDF, 1.17 MB

english, 2006

14

Regioselectivity and Reversibility of the Glutathione Conjugation of Quercetin Quinone Methide

Boersma, Marelle G., Vervoort, Jacques, Szymusiak, Henryk, Lemanska, Katarzyna, Tyrakowska, Bozena, Cenas, Narimantas, Segura-Aguilar, Juan, Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

15

Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours

Segura-Aguilar, Juan, Cremades, Antonio, Llombart-Bosch, Antonio, Monsalve, Elena, Ernster, Lars, Romero, Francisco J.

Journal:

Year:

1994

Language:

english

File:

PDF, 1022 KB

english, 1994

16

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

Cuevas, Carlos, Huenchuguala, Sandro, Muñoz, Patricia, Villa, Monica, Paris, Irmgard, Mannervik, Bengt, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

17

Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome

Segura-Aguilar, J., Baez, S., Widersten, M., Welch, C. J., Mannervik, B.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 722 KB

english, 1997

18

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson’s Disease?

Herrera, Andrea, Muñoz, Patricia, Steinbusch, Harry W. M., Segura-Aguilar, Juan

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

19

The importance of choosing a preclinical model that reflects what happens in Parkinson's disease

Segura-Aguilar, Juan

Journal:

Neurochemistry International

Year:

2019

Language:

english

File:

PDF, 964 KB

english, 2019

20

Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. A review

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

21

Neurotoxins and neurotoxic species implicated in neurodegeneration

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Year:

2004

Language:

english

File:

PDF, 179 KB

english, 2004

22

Dopamine-Dependent Iron Toxicity in Cells Derived from Rat Hypothalamus

Paris, Irmgard, Martinez-Alvarado, Pedro, Cárdenas, Sergio, Perez-Pastene, Carolina, Graumann, Rebecca, Fuentes, Patricio, Olea-Azar, Claudio, Caviedes, Pablo, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2005

Language:

english

File:

PDF, 215 KB

english, 2005

23

Commentary: A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease

Muñoz, Patricia, Segura-Aguilar, Juan

Journal:

Frontiers in Pharmacology

Year:

2016

Language:

english

File:

PDF, 208 KB

english, 2016

24

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

Ana María Cárdenas, David D. Allen, Christian Arriagada, Alexis Olivares, Lori B. Bennett, Raúl Caviedes, Alexies Dagnino-Subiabre, Isabel E. Mendoza, Juan Segura-Aguilar, Stanley I. Rapoport, Pablo C

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 486 KB

english, 2002

25

Molecular and Neurochemical Mechanisms in PD Pathogenesis

Irmgard Paris, Jorge Lozano, Carolina Perez-Pastene, Patricia Muñoz, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

26

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

Diana Metodiewa, Anil K. Jaiswal, Narimantas Cenas, Egle Dickancaité, Juan Segura-Aguilar

Journal:

Free Radical Biology and Medicine

Year:

1999

Language:

english

File:

PDF, 225 KB

english, 1999

27

Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

Vanda Miŝkinien≐, Eglë̇ Sergedien≐, Auŝra Nemeikait≐, Juan Segura-Aguilar, Narimantas Ĉ≐nas

Journal:

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

28

New preclinical model are required to discover neuroprotective compound in Parkinson’s disease

Segura-Aguilar, Juan

Journal:

Pharmacological Research

Year:

2017

Language:

english

File:

PDF, 186 KB

english, 2017

29

Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

Irmgard Paris, Alexies Dagnino-Subiabre, Katherine Marcelain, Lori B. Bennett, Pablo Caviedes, Raúl Caviedes, Claudio Olea Azar, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 694 KB

english, 2001

30

Glutathione Transferase M2-2 Catalyzes Conjugation of Dopamine and Dopa o-Quinones

Alexies Dagnino-Subiabre, Bruce K. Cassels, Sofia Baez, Ann-Sofie Johansson, Bengt Mannervik, Juan Segura-Aguilar

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

31

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

Zilvinas Anusevicius, Ans E.M.F Soffers, Narimantas Cénas, Jonas Sarlauskas, Juan Segura-Aguilar, Ivonne M.C.M Rietjens

Journal:

Year:

1998

Language:

english

File:

PDF, 111 KB

english, 1998

32

Inhibition of VMAT-2 and DT-Diaphorase Induce Cell Death in a Substantia Nigra-Derived Cell LineAn Experimental Cell Model for Dopamine Toxicity Studies

Fuentes, Patricio, Paris, Irmgard, Nassif, Melissa, Caviedes, Pablo, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 1.15 MB

english, 2007

33

Interactions of iron, dopamine and neuromelanin pathways in brain aging and parkinson's disease

F. A. Zucca, J. Segura-aguilar, E. Ferrari, P. Muñoz, I. Paris, D. Sulzer, T. Sarna, L. Casella, L. Zecca

Year:

2015

Language:

english

File:

PDF, 682 KB

english, 2015

34

MPP+-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity

R. Aguilar Hernández, M. J. Sánchez De Las Matas, C. Arriagada, C. Barcia, P. Caviedes, M. T. Herrero, J. Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 263 KB

english, 2003

35

Program and abstracts of the First Int’l Meeting: Mechanisms for Neurodegenerative Disorders—Alzheimer, Amyotropic Lateral Sclerosis (ALS) and Parkinson’s Disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 1.90 MB

english, 2002

36

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizabi

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 259 KB

english, 2012

37

Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

Juan Segura-Aguilar, Rudolf Kaiser, Christina Lind

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1992

Language:

english

File:

PDF, 863 KB

english, 1992

38

Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update

Segura-Aguilar, Juan, Kostrzewa, Richard M.

Journal:

Neurotoxicity Research

Year:

2015

Language:

english

File:

PDF, 602 KB

english, 2015

39

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease

Segura-Aguilar, Juan, Huenchuguala, Sandro

Journal:

Frontiers in Neuroscience

Year:

2018

Language:

english

File:

PDF, 676 KB

english, 2018

40

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

Briceño, Andrea, Muñoz, Patricia, Brito, Patricia, Huenchuguala, Sandro, Segura-Aguilar, Juan, Paris, Irmgard B.

Journal:

Neurotoxicity Research

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

41

On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo

Herrera-Soto, Andrea, Díaz-Veliz, Gabriela, Mora, Sergio, Muñoz, Patricia, Henny, Pablo, Steinbusch, Harry W. M., Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2017

Language:

english

File:

PDF, 820 KB

english, 2017

42

Erratum to: Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizabi

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 94 KB

english, 2012

43

Can we conclude a potential therapeutic action for Parkinson’s disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?

Segura-Aguilar, Juan

Journal:

Cell Death and Disease

Year:

2018

Language:

english

File:

PDF, 662 KB

english, 2018

44

Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson’s disease

Irmgard Paris, Sergio Cardenas, Jorge Lozano, Carolina Perez-Pastene, Rebecca Graumann, Alejandra Riveros, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2007

Language:

english

File:

PDF, 825 KB

english, 2007

45

The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters

Segura-Aguilar, Juan, Cortés-Vizcaino, Virginia, Llombart-Bosch, Antonio, Ernster, Lars, Monsalve, Elena, Romero, Francisco J.

Journal:

Year:

1990

Language:

english

File:

PDF, 3.56 MB

english, 1990

46

Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

Irmgard Paris, Pedro Martinez-Alvarado, Carolina Perez-Pastene, Marcelo N. N. Vieira, Claudio Olea-Azar, Rita Raisman-Vozari, Sergio Cardenas, Rebeca Graumann, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 430 KB

english, 2005

47

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

Pabla Aguirre, Pamela Urrutia, Victoria Tapia, Monica Villa, Irmgad Paris, Juan Segura-Aguilar, Marco T. Núñez

Journal:

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

48

The protective effect of superoxide dismutase and catalase against formation of reactive oxygen species during reduction of cyclized norepinephrine ortho-quinone of DT-diaphorase

Linderson, Ylva, Baez, Sofia, Segura-Aguilar, Juan

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1994

Language:

english

File:

PDF, 684 KB

english, 1994

49

On the Role of Aminochrome in Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Parkinson's Disease

Segura-Aguilar, Juan

Journal:

Frontiers in Neuroscience

Year:

2019

File:

PDF, 884 KB

2019

50

Neurotoxicological and neuroprotective elements in Parkinson’s disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски